Oxidized LDL affects multiple atherogenic cellular responses.
نویسندگان
چکیده
منابع مشابه
Roles of multiple oxidized LDL lipids in cellular injury: dominance of 7 beta-hydroperoxycholesterol.
The relative toxicities of several lipid oxidation products formed on oxidized LDL, their presence on oxidized LDL, and potential mechanisms of cell injury compared to oxidized LDL were examined. Toxicities to fibroblasts, with lipoprotein-deficient serum supplementation, were: 7 beta-hydroperoxycholesterol > 7 beta-hydroxycholesterol = 4-hydroxynonenal > 7-ketocholesterol > 5 alpha, 6 alpha-ep...
متن کاملCirculating oxidized LDL forms complexes with beta2-glycoprotein I: implication as an atherogenic autoantigen.
Beta2-glycoprotein I (beta2-GPI) is a major antigen for antiphospholipid antibodies (Abs, aPL) present in patients with antiphospholipid syndrome (APS). We recently reported (J. Lipid Res., 42: 697, 2001; J. Lipid Res., 43: 1486, 2002) that beta2-GPI specifically binds to Cu2+-oxidized LDL (oxLDL) and that the beta2-GPI ligands are omega-carboxylated 7-ketocholesteryl esters. In the present stu...
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Diabetes mellitus (DM) is the fifth deadliest disease in the United States with an annual economic cost estimated over $100 billion. Cardiovascular disease (CVD) represents the most life threatening consequence of DM accounting for the death of up to 65% of DM patients. Aggressive efforts aimed at treating and controlling the classic CVD risk factors over the last few decades have brought along...
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BACKGROUND Oxidized low-density lipoproteins (oxLDL) and oxLDL-containing immune complexes (oxLDL-IC) contribute to formation of lipid-laden macrophages (foam cells). It has been shown that oxLDL-IC are considerably more efficient than oxLDL in induction of foam cell formation, inflammatory cytokines secretion, and cell survival promotion. Whereas oxLDL is taken up by several scavenger receptor...
متن کاملThe preparation of copper-oxidized LDL for the measurement of oxidized LDL antibodies by EIA.
In the present study we try to define the optimal conditions for preparation of copper-oxidized low-density lipoprotein (oxLDL) to be used for the assay of oxLDL antibodies by enzyme immunoassay (EIA). Oxidation of LDL was monitored by measuring the formation of conjugated dienes at 234 nm and the generation of fluorescent products with emission at 430 nm when excitation is performed at 360 nm....
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ژورنال
عنوان ژورنال: Circulation
سال: 1991
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.83.6.2137